Drug interactions
Antithymocyte globulin rabbit + Sirolimus
Severity: Moderate
Antithymocyte globulin rabbit and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabbit antithymocyte globulin is commonly used for induction alongside sirolimus-based regimens, but together they intensify immunosuppression. This raises the risk of infection, cytopenias and lymphoproliferative disease.
What this interaction means in plain words
Antithymocyte globulin rabbit and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression through T-cell depletion and mTOR inhibition.
What to do
Use under transplant specialist supervision with antiviral and antimicrobial prophylaxis. Monitor blood counts and sirolimus trough levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Antithymocyte globulin rabbit with Sirolimus?
MediHelp rates the interaction as moderate. Antithymocyte globulin rabbit and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rabbit antithymocyte globulin is commonly used for induction alongside sirolimus-based regimens, but together they intensify immunosuppression. This raises the risk of infection, cytopenias and lymphoproliferative disease.
How serious is the interaction between Antithymocyte globulin rabbit and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use under transplant specialist supervision with antiviral and antimicrobial prophylaxis. Monitor blood counts and sirolimus trough levels.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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