Drug interactions
Antithymocyte globulin rabbit + Tacrolimus
Severity: Major
Antithymocyte globulin rabbit and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these agents produce profound immunosuppression, raising risk of opportunistic infection and lymphoproliferative disorders. The combination is standard in some transplant regimens but requires careful oversight.
What this interaction means in plain words
Antithymocyte globulin rabbit and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression through T-cell depletion and calcineurin inhibition.
What to do
Use under transplant protocols with antiviral and antimicrobial prophylaxis, and monitor for infection and tacrolimus levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Antithymocyte globulin rabbit and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Antithymocyte globulin rabbit with Tacrolimus?
MediHelp rates the interaction as major. Antithymocyte globulin rabbit and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Together these agents produce profound immunosuppression, raising risk of opportunistic infection and lymphoproliferative disorders. The combination is standard in some transplant regimens but requires careful oversight.
How serious is the interaction between Antithymocyte globulin rabbit and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use under transplant protocols with antiviral and antimicrobial prophylaxis, and monitor for infection and tacrolimus levels.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
