Drug interactions
Apalutamide + Ensitrelvir
Severity: Contraindicated
Apalutamide and Ensitrelvir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A inducer and is expected to substantially reduce ensitrelvir concentrations. This risks loss of virologic response.
What this interaction means in plain words
Apalutamide and Ensitrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Ensitrelvir belongs to Anti Virals.
Why it happens
Apalutamide induces CYP3A, increasing ensitrelvir clearance.
What to do
Avoid the combination and choose an alternative COVID-19 therapy. Do not use ensitrelvir in patients taking apalutamide.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ensitrelvir
- Carbamazepine + Ensitrelvir Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Ensitrelvir + Ivabradine Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Apalutamide with Ensitrelvir?
MediHelp rates the interaction as contraindicated. Apalutamide and Ensitrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide is a strong CYP3A inducer and is expected to substantially reduce ensitrelvir concentrations. This risks loss of virologic response.
How serious is the interaction between Apalutamide and Ensitrelvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative COVID-19 therapy. Do not use ensitrelvir in patients taking apalutamide.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Carbamazepine, Colchicine, Enzalutamide. The full list is on the Ensitrelvir page.
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