Drug reference
apalutamide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Gonadal Hormones)
Mechanism of action
Androgen receptor (AR) inhibitor that binds directly to the ligand-binding domain of the AR; inhibits AR nuclear translocation, inhibits DNA binding, and impedes AR-mediated transcription
Common side effects
- Anemia
- Leukopenia
- Fatigue
- Hypercholesterolemia, nonfasting
- Lymphopenia
- Hyperglycemia
- Hypertriglyceridemia
Known interactions (2)
- apalutamide + lorlatinib Contraindicated
- apalutamide + praziquantel Major
Related conditions
Frequently asked questions
What drug class is apalutamide?
apalutamide belongs to: Endocrine.
How does apalutamide work?
Androgen receptor (AR) inhibitor that binds directly to the ligand-binding domain of the AR; inhibits AR nuclear translocation, inhibits DNA binding, and impedes AR-mediated transcription
What are the common side effects of apalutamide?
Anemia, Leukopenia, Fatigue, Hypercholesterolemia, nonfasting, Lymphopenia, Hyperglycemia, Hypertriglyceridemia
Which drugs interact with apalutamide?
lorlatinib, praziquantel
Full monographs, dosing and an interaction checker in the MediHelp app
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