Drug interactions
Apixaban + Belzutifan
Severity: Moderate
Apixaban and Belzutifan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan induces CYP3A4 and may reduce apixaban concentrations. Lower exposure could reduce protection against stroke or venous thromboembolism.
What this interaction means in plain words
Apixaban and Belzutifan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Belzutifan belongs to Miscellaneous.
Why it happens
Belzutifan induces CYP3A4, increasing apixaban metabolism.
What to do
Monitor for loss of anticoagulant efficacy and consider an alternative anticoagulant if the combination cannot be avoided. Do not empirically raise the apixaban dose without specialist advice.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Apixaban with Belzutifan?
MediHelp rates the interaction as moderate. Apixaban and Belzutifan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan induces CYP3A4 and may reduce apixaban concentrations. Lower exposure could reduce protection against stroke or venous thromboembolism.
How serious is the interaction between Apixaban and Belzutifan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of anticoagulant efficacy and consider an alternative anticoagulant if the combination cannot be avoided. Do not empirically raise the apixaban dose without specialist advice.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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