Drug interactions
Apixaban + Dipyridamole
Severity: Moderate
Apixaban and Dipyridamole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole inhibits platelet aggregation and may increase bleeding when given with apixaban. The risk is greatest in older patients and those with renal impairment or prior bleeding.
What this interaction means in plain words
Apixaban and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Dipyridamole belongs to Cardiovascular.
Why it happens
Additive effects of antiplatelet activity (adenosine reuptake and phosphodiesterase inhibition) and factor Xa inhibition.
What to do
Use together only when there is a clear indication, and monitor for bleeding and hemoglobin changes. Review the need for the antiplatelet periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Apixaban with Dipyridamole?
MediHelp rates the interaction as moderate. Apixaban and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipyridamole inhibits platelet aggregation and may increase bleeding when given with apixaban. The risk is greatest in older patients and those with renal impairment or prior bleeding.
How serious is the interaction between Apixaban and Dipyridamole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when there is a clear indication, and monitor for bleeding and hemoglobin changes. Review the need for the antiplatelet periodically.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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