Drug interactions
Apixaban + Ivosidenib
Severity: Moderate
Apixaban and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower apixaban concentrations. This could reduce anticoagulant protection and risk thromboembolism.
What this interaction means in plain words
Apixaban and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Ivosidenib belongs to Oncology.
Why it happens
Induction of CYP3A4 increases apixaban metabolism and lowers exposure.
What to do
Monitor for thromboembolic events and consider an alternative anticoagulant if the patient has a high thrombotic risk. Avoid if possible when stroke risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Apixaban with Ivosidenib?
MediHelp rates the interaction as moderate. Apixaban and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower apixaban concentrations. This could reduce anticoagulant protection and risk thromboembolism.
How serious is the interaction between Apixaban and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for thromboembolic events and consider an alternative anticoagulant if the patient has a high thrombotic risk. Avoid if possible when stroke risk is high.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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