Drug interactions
Apixaban + Sotorasib
Severity: Moderate
Apixaban and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inhibitor in vitro and may raise apixaban exposure. The clinical effect on apixaban is not well characterised, but bleeding risk could increase.
What this interaction means in plain words
Apixaban and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Sotorasib belongs to Oncology.
Why it happens
Possible inhibition of P-gp efflux of apixaban, with an effect on CYP3A4 induction also possible.
What to do
Monitor for bleeding or reduced anticoagulant effect and check hemoglobin periodically. Consider an alternative anticoagulant in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Apixaban with Sotorasib?
MediHelp rates the interaction as moderate. Apixaban and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-gp inhibitor in vitro and may raise apixaban exposure. The clinical effect on apixaban is not well characterised, but bleeding risk could increase.
How serious is the interaction between Apixaban and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding or reduced anticoagulant effect and check hemoglobin periodically. Consider an alternative anticoagulant in patients with other risk factors.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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