Drug interactions
Apraclonidine + Linezolid
Severity: Major
Apraclonidine and Linezolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apraclonidine labeling contraindicates use with MAO inhibitors, and linezolid has MAO-inhibiting activity. Concern is for altered catecholamine handling and blood pressure changes, although ophthalmic systemic exposure is small.
What this interaction means in plain words
Apraclonidine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apraclonidine belongs to Cardiovascular; Linezolid belongs to Anti Bacterial.
Why it happens
Mechanism not firmly established; likely MAO inhibition affecting adrenergic agonist disposition.
What to do
Avoid concurrent use where possible, following the apraclonidine labeling. If both are needed, monitor blood pressure and heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Apraclonidine
- Apraclonidine + Isocarboxazid Contraindicated
- Apraclonidine + Phenelzine Major
- Apraclonidine + Rasagiline Major
- Apraclonidine + Selegiline Major
- Apraclonidine + Tranylcypromine Major
Frequently asked questions
Can I take Apraclonidine with Linezolid?
MediHelp rates the interaction as major. Apraclonidine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine labeling contraindicates use with MAO inhibitors, and linezolid has MAO-inhibiting activity. Concern is for altered catecholamine handling and blood pressure changes, although ophthalmic systemic exposure is small.
How serious is the interaction between Apraclonidine and Linezolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, following the apraclonidine labeling. If both are needed, monitor blood pressure and heart rate.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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