Drug interactions
Apraclonidine + Tranylcypromine
Severity: Major
Apraclonidine and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apraclonidine is an alpha-2 agonist eye drop with limited systemic exposure, but labeling contraindicates its use with MAOIs. MAOIs may alter catecholamine handling and unpredictably change blood pressure responses.
What this interaction means in plain words
Apraclonidine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apraclonidine belongs to Cardiovascular; Tranylcypromine belongs to Central Nervous System.
Why it happens
The mechanism is not well established; MAOI-related changes in catecholamine metabolism may alter responses to alpha-agonists.
What to do
Avoid apraclonidine in patients on tranylcypromine and select another ocular hypotensive agent such as a prostaglandin analogue or beta-blocker as appropriate. If it is unavoidable, monitor blood pressure and heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Apraclonidine
- Apraclonidine + Isocarboxazid Contraindicated
- Apraclonidine + Linezolid Major
- Apraclonidine + Phenelzine Major
- Apraclonidine + Rasagiline Major
- Apraclonidine + Selegiline Major
Frequently asked questions
Can I take Apraclonidine with Tranylcypromine?
MediHelp rates the interaction as major. Apraclonidine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine is an alpha-2 agonist eye drop with limited systemic exposure, but labeling contraindicates its use with MAOIs. MAOIs may alter catecholamine handling and unpredictably change blood pressure responses.
How serious is the interaction between Apraclonidine and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apraclonidine in patients on tranylcypromine and select another ocular hypotensive agent such as a prostaglandin analogue or beta-blocker as appropriate. If it is unavoidable, monitor blood pressure and heart rate.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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