Drug interactions
Apremilast + Oxcarbazepine
Severity: Moderate
Apremilast and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce apremilast exposure and lower its efficacy in psoriasis or related conditions, though the effect is expected to be smaller than with strong inducers.
What this interaction means in plain words
Apremilast and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apremilast belongs to Miscellaneous; Oxcarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by oxcarbazepine increases apremilast clearance.
What to do
Monitor clinical response to apremilast. Consider an alternative anticonvulsant if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Apremilast
- Apalutamide + Apremilast Major
- Apremilast + Carbamazepine Major
- Apremilast + Efavirenz Major
- Apremilast + Enzalutamide Major
- Apremilast + Phenytoin Major
- Apremilast + Rifampicin Major
Frequently asked questions
Can I take Apremilast with Oxcarbazepine?
MediHelp rates the interaction as moderate. Apremilast and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce apremilast exposure and lower its efficacy in psoriasis or related conditions, though the effect is expected to be smaller than with strong inducers.
How serious is the interaction between Apremilast and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to apremilast. Consider an alternative anticonvulsant if efficacy declines.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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