Drug interactions
Apalutamide + Apremilast
Severity: Major
Apalutamide and Apremilast: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apremilast is cleared partly by CYP3A4, and apalutamide strongly induces this enzyme. Apremilast exposure falls and its therapeutic effect may be lost.
What this interaction means in plain words
Apalutamide and Apremilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Apremilast belongs to Miscellaneous.
Why it happens
Apalutamide induces CYP3A4, reducing apremilast concentrations.
What to do
Avoid concomitant use, as apremilast labeling advises against strong CYP3A4 inducers. Consider another agent for the inflammatory condition.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apalutamide and Apremilast, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Apremilast
- Apremilast + Carbamazepine Major
- Apremilast + Efavirenz Major
- Apremilast + Enzalutamide Major
- Apremilast + Phenytoin Major
- Apremilast + Rifampicin Major
- Apremilast + Secobarbital Major
Frequently asked questions
Can I take Apalutamide with Apremilast?
MediHelp rates the interaction as major. Apalutamide and Apremilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apremilast is cleared partly by CYP3A4, and apalutamide strongly induces this enzyme. Apremilast exposure falls and its therapeutic effect may be lost.
How serious is the interaction between Apalutamide and Apremilast?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use, as apremilast labeling advises against strong CYP3A4 inducers. Consider another agent for the inflammatory condition.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
