Drug interactions
Apremilast + Enzalutamide
Severity: Major
Apremilast and Enzalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and lowers apremilast exposure substantially. This can lead to loss of therapeutic effect in psoriasis or psoriatic arthritis.
What this interaction means in plain words
Apremilast and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apremilast belongs to Miscellaneous; Enzalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 by enzalutamide increases the metabolic clearance of apremilast.
What to do
Avoid the combination; apremilast labeling advises against use with strong CYP inducers. Choose an alternative antipsoriatic agent if enzalutamide must continue.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Apremilast
- Apalutamide + Apremilast Major
- Apremilast + Carbamazepine Major
- Apremilast + Efavirenz Major
- Apremilast + Phenytoin Major
- Apremilast + Rifampicin Major
- Apremilast + Secobarbital Major
Frequently asked questions
Can I take Apremilast with Enzalutamide?
MediHelp rates the interaction as major. Apremilast and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and lowers apremilast exposure substantially. This can lead to loss of therapeutic effect in psoriasis or psoriatic arthritis.
How serious is the interaction between Apremilast and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; apremilast labeling advises against use with strong CYP inducers. Choose an alternative antipsoriatic agent if enzalutamide must continue.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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