Drug interactions
Arformoterol + Clomipramine
Severity: Moderate
Arformoterol and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of long-acting beta-agonists such as arformoterol, including tachycardia, arrhythmias and QT prolongation. The risk is greater in patients with heart disease.
What this interaction means in plain words
Arformoterol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Clomipramine belongs to Central Nervous System.
Why it happens
Additive adrenergic and QT-prolonging effects.
What to do
Monitor heart rate, blood pressure and ECG in at-risk patients, and keep potassium in the normal range. Consider an alternative bronchodilator if cardiac symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Clomipramine?
MediHelp rates the interaction as moderate. Arformoterol and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of long-acting beta-agonists such as arformoterol, including tachycardia, arrhythmias and QT prolongation. The risk is greater in patients with heart disease.
How serious is the interaction between Arformoterol and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in at-risk patients, and keep potassium in the normal range. Consider an alternative bronchodilator if cardiac symptoms occur.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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