Drug interactions
Arformoterol + Crizotinib
Severity: Moderate
Arformoterol and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib prolongs the QT interval, and arformoterol, a long-acting beta-agonist, can cause tachycardia, hypokalemia and QT prolongation. Together they may raise arrhythmia risk, particularly in patients with cardiac disease.
What this interaction means in plain words
Arformoterol and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Crizotinib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-agonist related hypokalemia contributing.
What to do
Monitor ECG and serum potassium, and correct electrolyte disturbances. Use arformoterol at the labeled dose only.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Crizotinib?
MediHelp rates the interaction as moderate. Arformoterol and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib prolongs the QT interval, and arformoterol, a long-acting beta-agonist, can cause tachycardia, hypokalemia and QT prolongation. Together they may raise arrhythmia risk, particularly in patients with cardiac disease.
How serious is the interaction between Arformoterol and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium, and correct electrolyte disturbances. Use arformoterol at the labeled dose only.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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