Drug interactions
Arformoterol + Esmolol
Severity: Moderate
Arformoterol and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol can antagonise the bronchodilating effect of arformoterol, a long-acting beta-2 agonist. At higher doses esmolol loses beta-1 selectivity, which increases the risk of bronchospasm in patients with reactive airway disease.
What this interaction means in plain words
Arformoterol and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Esmolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta adrenergic receptors with loss of selectivity at higher esmolol doses.
What to do
Use the lowest effective esmolol dose and monitor for bronchospasm and loss of asthma or COPD control. Consider an alternative to esmolol in patients with severe reactive airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Esmolol?
MediHelp rates the interaction as moderate. Arformoterol and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol can antagonise the bronchodilating effect of arformoterol, a long-acting beta-2 agonist. At higher doses esmolol loses beta-1 selectivity, which increases the risk of bronchospasm in patients with reactive airway disease.
How serious is the interaction between Arformoterol and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective esmolol dose and monitor for bronchospasm and loss of asthma or COPD control. Consider an alternative to esmolol in patients with severe reactive airway disease.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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