Drug interactions
Arformoterol + Labetalol
Severity: Moderate
Arformoterol and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol can antagonize the bronchodilating effect of arformoterol and may cause bronchospasm in susceptible patients. This can lead to loss of asthma or COPD control.
What this interaction means in plain words
Arformoterol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Labetalol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by a nonselective beta-blocker.
What to do
Prefer a cardioselective beta-blocker or a non-beta-blocker antihypertensive in patients needing arformoterol. If coadministered, monitor respiratory symptoms and lung function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Labetalol?
MediHelp rates the interaction as moderate. Arformoterol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol can antagonize the bronchodilating effect of arformoterol and may cause bronchospasm in susceptible patients. This can lead to loss of asthma or COPD control.
How serious is the interaction between Arformoterol and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a cardioselective beta-blocker or a non-beta-blocker antihypertensive in patients needing arformoterol. If coadministered, monitor respiratory symptoms and lung function.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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