Drug interactions
Arformoterol + Metoprolol
Severity: Moderate
Arformoterol and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol can antagonize arformoterol, reducing bronchodilation and possibly triggering bronchospasm in susceptible patients. Arformoterol may also provoke tachycardia or hypokalemia, which complicates cardiac management.
What this interaction means in plain words
Arformoterol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Metoprolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors, more evident when metoprolol selectivity is lost at higher doses.
What to do
Use the lowest effective metoprolol dose and monitor respiratory function and heart rate. Prefer a non-beta-blocker alternative in patients with significant airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Metoprolol?
MediHelp rates the interaction as moderate. Arformoterol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol can antagonize arformoterol, reducing bronchodilation and possibly triggering bronchospasm in susceptible patients. Arformoterol may also provoke tachycardia or hypokalemia, which complicates cardiac management.
How serious is the interaction between Arformoterol and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective metoprolol dose and monitor respiratory function and heart rate. Prefer a non-beta-blocker alternative in patients with significant airway disease.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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