Drug interactions
Arformoterol + Perphenazine
Severity: Moderate
Arformoterol and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol can prolong the QT interval and lower serum potassium, and perphenazine can also affect cardiac repolarisation. Together they may modestly raise the risk of arrhythmia, particularly in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Arformoterol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalaemia.
What to do
Monitor ECG in patients with cardiac risk factors and check potassium and magnesium. Avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Perphenazine?
MediHelp rates the interaction as moderate. Arformoterol and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arformoterol can prolong the QT interval and lower serum potassium, and perphenazine can also affect cardiac repolarisation. Together they may modestly raise the risk of arrhythmia, particularly in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Arformoterol and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and check potassium and magnesium. Avoid other QT-prolonging drugs where possible.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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