Drug interactions
Argatroban + Capecitabine
Severity: Moderate
Argatroban and Capecitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capecitabine can cause thrombocytopenia and, with warfarin in particular, altered coagulation, so bleeding risk may be higher in anticoagulated patients. Argatroban adds anticoagulant effect, which makes bleeding more likely if platelets fall.
What this interaction means in plain words
Argatroban and Capecitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Capecitabine belongs to Oncology.
Why it happens
Additive bleeding risk from chemotherapy-related thrombocytopenia plus direct thrombin inhibition; no specific kinetic interaction is established.
What to do
Monitor platelet counts and coagulation tests such as aPTT, and watch for bleeding. Adjust the argatroban dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capecitabine
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Capecitabine?
MediHelp rates the interaction as moderate. Argatroban and Capecitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capecitabine can cause thrombocytopenia and, with warfarin in particular, altered coagulation, so bleeding risk may be higher in anticoagulated patients. Argatroban adds anticoagulant effect, which makes bleeding more likely if platelets fall.
How serious is the interaction between Argatroban and Capecitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and coagulation tests such as aPTT, and watch for bleeding. Adjust the argatroban dose as needed.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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