Drug interactions
Argatroban + Cefuroxime
Severity: Minor
Argatroban and Cefuroxime: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefuroxime has not been shown to produce meaningful hypoprothrombinemia, and a clinically relevant effect on argatroban is not documented. Argatroban already raises the INR, which complicates interpretation. The concern is mainly theoretical.
What this interaction means in plain words
Argatroban and Cefuroxime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Cefuroxime belongs to Anti Bacterial.
Why it happens
Theoretical additive effect on coagulation; cefuroxime lacks the side chain associated with vitamin K antagonism.
What to do
Titrate argatroban to aPTT as usual and monitor for bleeding; no cefuroxime-specific change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Cefuroxime?
MediHelp rates the interaction as minor. Argatroban and Cefuroxime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefuroxime has not been shown to produce meaningful hypoprothrombinemia, and a clinically relevant effect on argatroban is not documented. Argatroban already raises the INR, which complicates interpretation. The concern is mainly theoretical.
How serious is the interaction between Argatroban and Cefuroxime?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate argatroban to aPTT as usual and monitor for bleeding; no cefuroxime-specific change is needed.
What other medicines interact with Cefuroxime?
MediHelp also lists interactions of Cefuroxime with, for example, Aluminum hydroxide, Amikacin, Bcg vaccine live. The full list is on the Cefuroxime page.
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