Drug interactions
Argatroban + Cyclophosphamide
Severity: Moderate
Argatroban and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide suppresses the bone marrow and can cause thrombocytopenia, which increases bleeding risk in patients receiving the anticoagulant argatroban. The effect arises from combined hemostatic impairment rather than a direct drug interaction.
What this interaction means in plain words
Argatroban and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Cyclophosphamide belongs to Oncology.
Why it happens
Chemotherapy-induced thrombocytopenia adds to the anticoagulant effect of the direct thrombin inhibitor.
What to do
Monitor platelet counts and aPTT, and adjust or hold argatroban if platelets fall markedly or bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Cyclophosphamide?
MediHelp rates the interaction as moderate. Argatroban and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclophosphamide suppresses the bone marrow and can cause thrombocytopenia, which increases bleeding risk in patients receiving the anticoagulant argatroban. The effect arises from combined hemostatic impairment rather than a direct drug interaction.
How serious is the interaction between Argatroban and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and aPTT, and adjust or hold argatroban if platelets fall markedly or bleeding occurs.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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