Drug interactions
Argatroban + Deflazacort
Severity: Moderate
Argatroban and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter coagulation and also raise the risk of gastrointestinal bleeding, which may add to the bleeding risk of a direct thrombin inhibitor. The net effect on anticoagulation is unpredictable.
What this interaction means in plain words
Argatroban and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Pharmacodynamic effects of corticosteroids on coagulability and mucosal integrity combined with argatroban anticoagulation; mechanism not firmly established.
What to do
Monitor aPTT or ACT per argatroban protocol and watch for signs of bleeding. Consider gastroprotection in patients at high GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Deflazacort?
MediHelp rates the interaction as moderate. Argatroban and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter coagulation and also raise the risk of gastrointestinal bleeding, which may add to the bleeding risk of a direct thrombin inhibitor. The net effect on anticoagulation is unpredictable.
How serious is the interaction between Argatroban and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT or ACT per argatroban protocol and watch for signs of bleeding. Consider gastroprotection in patients at high GI risk.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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