Drug interactions
Argatroban + Erythromycin
Severity: Minor
Argatroban and Erythromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Argatroban is cleared mainly by hepatic metabolism, with CYP3A4/5 playing a minor role. Erythromycin did not meaningfully change argatroban exposure in labeling data, so a clinically important effect is not expected.
What this interaction means in plain words
Argatroban and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Erythromycin belongs to Anti Bacterial.
Why it happens
Theoretical minor CYP3A4 inhibition; studies showed no significant effect on argatroban.
What to do
No dose adjustment is needed; continue routine aPTT monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Erythromycin?
MediHelp rates the interaction as minor. Argatroban and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Argatroban is cleared mainly by hepatic metabolism, with CYP3A4/5 playing a minor role. Erythromycin did not meaningfully change argatroban exposure in labeling data, so a clinically important effect is not expected.
How serious is the interaction between Argatroban and Erythromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; continue routine aPTT monitoring.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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