Drug interactions
Argatroban + Fish oil
Severity: Minor
Argatroban and Fish oil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose omega-3 fatty acids have mild antiplatelet effects and may modestly add to the bleeding tendency of a parenteral anticoagulant. The clinical significance is generally small at usual supplement doses.
What this interaction means in plain words
Argatroban and Fish oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Fish oil belongs to Gastrointestinal Tract.
Why it happens
Additive pharmacodynamic effect: omega-3 fatty acids mildly impair platelet aggregation while argatroban directly inhibits thrombin.
What to do
Monitor for bleeding and aPTT as per routine argatroban care; consider holding high-dose fish oil supplements during intensive anticoagulation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Fish oil
- Antithrombin alfa + Fish oil Moderate
- Antithrombin iii + Fish oil Moderate
- Aspirin / citric acid / sodium bicarbonate + Fish oil Moderate
- Aspirin + Fish oil Moderate
- Betrixaban + Fish oil Moderate
- Bivalirudin + Fish oil Moderate
Frequently asked questions
Can I take Argatroban with Fish oil?
MediHelp rates the interaction as minor. Argatroban and Fish oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High-dose omega-3 fatty acids have mild antiplatelet effects and may modestly add to the bleeding tendency of a parenteral anticoagulant. The clinical significance is generally small at usual supplement doses.
How serious is the interaction between Argatroban and Fish oil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and aPTT as per routine argatroban care; consider holding high-dose fish oil supplements during intensive anticoagulation.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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