Drug interactions
Argatroban + Flurbiprofen
Severity: Major
Argatroban and Flurbiprofen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Argatroban is a direct thrombin inhibitor and flurbiprofen inhibits platelet function and can injure the gastric mucosa. Combined use increases the risk of clinically significant bleeding, including gastrointestinal hemorrhage.
What this interaction means in plain words
Argatroban and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment: direct thrombin inhibition plus NSAID antiplatelet effect and GI mucosal damage.
What to do
Avoid concurrent NSAID use during argatroban therapy where possible. If unavoidable, monitor aPTT, hemoglobin and for signs of bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Flurbiprofen?
MediHelp rates the interaction as major. Argatroban and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Argatroban is a direct thrombin inhibitor and flurbiprofen inhibits platelet function and can injure the gastric mucosa. Combined use increases the risk of clinically significant bleeding, including gastrointestinal hemorrhage.
How serious is the interaction between Argatroban and Flurbiprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAID use during argatroban therapy where possible. If unavoidable, monitor aPTT, hemoglobin and for signs of bleeding.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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