Drug interactions
Argatroban + Ibrutinib
Severity: Moderate
Argatroban and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and is associated with bleeding events, including major hemorrhage. Combined with a direct thrombin inhibitor, the risk of bleeding is increased.
What this interaction means in plain words
Argatroban and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Ibrutinib belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: BTK inhibition by ibrutinib impairs platelet aggregation while argatroban inhibits thrombin.
What to do
Monitor closely for bleeding signs and check platelet counts and aPTT; reassess the need for anticoagulation and consider holding ibrutinib around procedures or if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Argatroban with Ibrutinib?
MediHelp rates the interaction as moderate. Argatroban and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and is associated with bleeding events, including major hemorrhage. Combined with a direct thrombin inhibitor, the risk of bleeding is increased.
How serious is the interaction between Argatroban and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding signs and check platelet counts and aPTT; reassess the need for anticoagulation and consider holding ibrutinib around procedures or if bleeding occurs.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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