Drug interactions
Argatroban + Ibuprofen
Severity: Major
Argatroban and Ibuprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen impairs platelet function and can irritate the gastrointestinal mucosa, while argatroban is a direct thrombin inhibitor. The combination raises the risk of bleeding, especially gastrointestinal bleeding.
What this interaction means in plain words
Argatroban and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment from reversible platelet inhibition by the NSAID and thrombin inhibition by argatroban.
What to do
Avoid ibuprofen during argatroban therapy where possible and use paracetamol for analgesia. If unavoidable, monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Ibuprofen?
MediHelp rates the interaction as major. Argatroban and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibuprofen impairs platelet function and can irritate the gastrointestinal mucosa, while argatroban is a direct thrombin inhibitor. The combination raises the risk of bleeding, especially gastrointestinal bleeding.
How serious is the interaction between Argatroban and Ibuprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ibuprofen during argatroban therapy where possible and use paracetamol for analgesia. If unavoidable, monitor for bleeding and hemoglobin.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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