Drug interactions
Argatroban + Meclofenamic acid
Severity: Major
Argatroban and Meclofenamic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate inhibits platelet function and can injure the gastric mucosa, while argatroban is a direct thrombin inhibitor. Used together, they increase the risk of clinically significant bleeding, particularly in the GI tract.
What this interaction means in plain words
Argatroban and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive impairment of hemostasis from NSAID platelet inhibition and argatroban thrombin inhibition.
What to do
Avoid NSAIDs during argatroban therapy where possible. If concurrent use is necessary, monitor aPTT, hemoglobin and signs of bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Meclofenamic acid?
MediHelp rates the interaction as major. Argatroban and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Meclofenamate inhibits platelet function and can injure the gastric mucosa, while argatroban is a direct thrombin inhibitor. Used together, they increase the risk of clinically significant bleeding, particularly in the GI tract.
How serious is the interaction between Argatroban and Meclofenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs during argatroban therapy where possible. If concurrent use is necessary, monitor aPTT, hemoglobin and signs of bleeding.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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