Drug interactions
Argatroban + Prednisolone
Severity: Moderate
Argatroban and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can influence coagulation and also increase bleeding risk through gastric mucosal injury and vascular fragility, so the response to anticoagulants may be altered. The effect with argatroban is not well characterized.
What this interaction means in plain words
Argatroban and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Prednisolone belongs to Endocrine.
Why it happens
Pharmacodynamic effects of corticosteroids on coagulation and vascular integrity; no established pharmacokinetic interaction.
What to do
Monitor aPTT and watch for bleeding, particularly gastrointestinal bleeding, when corticosteroids are started or stopped. Adjust argatroban to the aPTT target.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Prednisolone?
MediHelp rates the interaction as moderate. Argatroban and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can influence coagulation and also increase bleeding risk through gastric mucosal injury and vascular fragility, so the response to anticoagulants may be altered. The effect with argatroban is not well characterized.
How serious is the interaction between Argatroban and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT and watch for bleeding, particularly gastrointestinal bleeding, when corticosteroids are started or stopped. Adjust argatroban to the aPTT target.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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