Drug interactions
Argatroban + Primidone
Severity: Minor
Argatroban and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital, which induces hepatic enzymes and could theoretically lower argatroban exposure. Because most argatroban clearance is not CYP dependent, a meaningful loss of effect is unlikely.
What this interaction means in plain words
Argatroban and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
Theoretical enzyme induction by primidone and its metabolite phenobarbital increasing argatroban metabolism.
What to do
No empirical dose change. Titrate argatroban to the aPTT and recheck if the anticonvulsant is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Argatroban with Primidone?
MediHelp rates the interaction as minor. Argatroban and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone is metabolized to phenobarbital, which induces hepatic enzymes and could theoretically lower argatroban exposure. Because most argatroban clearance is not CYP dependent, a meaningful loss of effect is unlikely.
How serious is the interaction between Argatroban and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change. Titrate argatroban to the aPTT and recheck if the anticonvulsant is started or stopped.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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