Drug interactions
Argatroban + Quinine
Severity: Moderate
Argatroban and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine may increase the anticoagulant effect of argatroban, and quinine itself can rarely cause thrombocytopenia and bleeding. The clinical significance is not well characterized.
What this interaction means in plain words
Argatroban and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Mechanism is not well established; possible additive effects on coagulation and platelet counts.
What to do
Monitor aPTT and platelet counts and adjust the argatroban dose to the target range. Watch for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Quinine?
MediHelp rates the interaction as moderate. Argatroban and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine may increase the anticoagulant effect of argatroban, and quinine itself can rarely cause thrombocytopenia and bleeding. The clinical significance is not well characterized.
How serious is the interaction between Argatroban and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT and platelet counts and adjust the argatroban dose to the target range. Watch for signs of bleeding.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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