Drug interactions
Argatroban + Rifabutin
Severity: Minor
Argatroban and Rifabutin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is an inducer of CYP3A4 and could theoretically lower argatroban exposure. However, argatroban is cleared mainly by hepatic metabolism through hydroxylation and CYP3A4/5 contributes only a small share, so a meaningful loss of effect is unlikely.
What this interaction means in plain words
Argatroban and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Rifabutin belongs to Anti Bacterial.
Why it happens
Possible induction of CYP3A4/5 by rifabutin increasing argatroban metabolism, which is a minor elimination pathway.
What to do
No dose change is needed; titrate argatroban to aPTT as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Argatroban and Rifabutin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Argatroban with Rifabutin?
MediHelp rates the interaction as minor. Argatroban and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifabutin is an inducer of CYP3A4 and could theoretically lower argatroban exposure. However, argatroban is cleared mainly by hepatic metabolism through hydroxylation and CYP3A4/5 contributes only a small share, so a meaningful loss of effect is unlikely.
How serious is the interaction between Argatroban and Rifabutin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; titrate argatroban to aPTT as usual.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
