Drug interactions
Argatroban + Triamcinolone
Severity: Moderate
Argatroban and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can alter coagulation and may also weaken vascular integrity, so the effect on anticoagulation is unpredictable. Bleeding risk may rise, particularly with gastrointestinal mucosal injury or with high or prolonged steroid exposure.
What this interaction means in plain words
Argatroban and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Triamcinolone belongs to Endocrine.
Why it happens
Pharmacodynamic effects of corticosteroids on coagulability and vascular fragility; the mechanism is not firmly established.
What to do
Monitor aPTT or the relevant coagulation parameters and watch for bleeding. Adjust argatroban dosing according to the monitored values.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Triamcinolone?
MediHelp rates the interaction as moderate. Argatroban and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can alter coagulation and may also weaken vascular integrity, so the effect on anticoagulation is unpredictable. Bleeding risk may rise, particularly with gastrointestinal mucosal injury or with high or prolonged steroid exposure.
How serious is the interaction between Argatroban and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT or the relevant coagulation parameters and watch for bleeding. Adjust argatroban dosing according to the monitored values.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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