Drug interactions
Arginine + Nitroglycerin
Severity: Moderate
Arginine and Nitroglycerin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arginine is the substrate for nitric oxide synthesis and can cause vasodilation. Combined with intravenous nitroglycerin it may cause additive blood pressure lowering.
What this interaction means in plain words
Arginine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation via increased nitric oxide availability alongside direct nitric oxide donation.
What to do
Monitor blood pressure and heart rate during concurrent use. Adjust nitroglycerin infusion if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Frequently asked questions
Can I take Arginine with Nitroglycerin?
MediHelp rates the interaction as moderate. Arginine and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arginine is the substrate for nitric oxide synthesis and can cause vasodilation. Combined with intravenous nitroglycerin it may cause additive blood pressure lowering.
How serious is the interaction between Arginine and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during concurrent use. Adjust nitroglycerin infusion if hypotension occurs.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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