Drug interactions
Aripiprazole + Asenapine
Severity: Moderate
Aripiprazole and Asenapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antipsychotics can affect cardiac repolarization, although aripiprazole has minimal effect on QT. Combined use of two antipsychotics adds modest arrhythmia risk and additive side effects.
What this interaction means in plain words
Aripiprazole and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Asenapine belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation, mainly from asenapine.
What to do
Check an ECG if there are other QT risk factors and keep electrolytes normal. Avoid unnecessary antipsychotic polypharmacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Aripiprazole with Asenapine?
MediHelp rates the interaction as moderate. Aripiprazole and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both antipsychotics can affect cardiac repolarization, although aripiprazole has minimal effect on QT. Combined use of two antipsychotics adds modest arrhythmia risk and additive side effects.
How serious is the interaction between Aripiprazole and Asenapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG if there are other QT risk factors and keep electrolytes normal. Avoid unnecessary antipsychotic polypharmacy.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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