Drug interactions
Aripiprazole + Belzutifan
Severity: Moderate
Aripiprazole and Belzutifan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan may induce CYP3A4 and lower aripiprazole concentrations, potentially reducing control of psychiatric symptoms. The size of the effect for aripiprazole is not well defined.
What this interaction means in plain words
Aripiprazole and Belzutifan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Belzutifan belongs to Miscellaneous.
Why it happens
Belzutifan induces CYP3A4, increasing aripiprazole clearance.
What to do
Monitor for loss of psychiatric symptom control and increase the aripiprazole dose if needed. Reduce the dose again if belzutifan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Belzutifan
Frequently asked questions
Can I take Aripiprazole with Belzutifan?
MediHelp rates the interaction as moderate. Aripiprazole and Belzutifan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan may induce CYP3A4 and lower aripiprazole concentrations, potentially reducing control of psychiatric symptoms. The size of the effect for aripiprazole is not well defined.
How serious is the interaction between Aripiprazole and Belzutifan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric symptom control and increase the aripiprazole dose if needed. Reduce the dose again if belzutifan is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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