Drug interactions
Aripiprazole + Chlorpropamide
Severity: Moderate
Aripiprazole and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics, including aripiprazole, can alter glucose regulation and may cause hyperglycemia, which can reduce the effectiveness of sulfonylureas such as chlorpropamide. Glycemic control may therefore worsen in diabetic patients.
What this interaction means in plain words
Aripiprazole and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Chlorpropamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism of glucose-lowering effect through antipsychotic-related metabolic disturbance.
What to do
Monitor blood glucose and HbA1c after starting aripiprazole and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Aripiprazole with Chlorpropamide?
MediHelp rates the interaction as moderate. Aripiprazole and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics, including aripiprazole, can alter glucose regulation and may cause hyperglycemia, which can reduce the effectiveness of sulfonylureas such as chlorpropamide. Glycemic control may therefore worsen in diabetic patients.
How serious is the interaction between Aripiprazole and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting aripiprazole and adjust the antidiabetic regimen as needed.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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