Drug interactions
Aripiprazole + Clozapine
Severity: Minor
Aripiprazole and Clozapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine can prolong the QT interval, whereas aripiprazole has little QT effect, so additive risk is small. The combination is used in practice, and the main concerns are additive sedation and metabolic effects.
What this interaction means in plain words
Aripiprazole and Clozapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Clozapine belongs to Central Nervous System.
Why it happens
Possible small additive QT effect, mainly from clozapine.
What to do
Monitor ECG if other QT risk factors exist, and monitor metabolic parameters and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Aripiprazole with Clozapine?
MediHelp rates the interaction as minor. Aripiprazole and Clozapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clozapine can prolong the QT interval, whereas aripiprazole has little QT effect, so additive risk is small. The combination is used in practice, and the main concerns are additive sedation and metabolic effects.
How serious is the interaction between Aripiprazole and Clozapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG if other QT risk factors exist, and monitor metabolic parameters and sedation.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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