Drug interactions
Aripiprazole + Cyclosporin
Severity: Minor
Aripiprazole and Cyclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may modestly raise aripiprazole concentrations, potentially increasing sedation, akathisia or other adverse effects.
What this interaction means in plain words
Aripiprazole and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine's weak to moderate CYP3A4 inhibition reduces aripiprazole clearance.
What to do
Monitor for aripiprazole adverse effects and reduce the dose if they occur; routine empirical dose changes are generally unnecessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Cyclosporin?
MediHelp rates the interaction as minor. Aripiprazole and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine may modestly raise aripiprazole concentrations, potentially increasing sedation, akathisia or other adverse effects.
How serious is the interaction between Aripiprazole and Cyclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aripiprazole adverse effects and reduce the dose if they occur; routine empirical dose changes are generally unnecessary.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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