Drug interactions
Aripiprazole + Diphenoxylate
Severity: Minor
Aripiprazole and Diphenoxylate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid and can cause drowsiness and dizziness at higher doses. With aripiprazole, sedation may be additive.
What this interaction means in plain words
Aripiprazole and Diphenoxylate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid and antipsychotic effects.
What to do
Keep to labeled diphenoxylate doses and warn the patient about drowsiness and impaired alertness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Aripiprazole with Diphenoxylate?
MediHelp rates the interaction as minor. Aripiprazole and Diphenoxylate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diphenoxylate is an opioid and can cause drowsiness and dizziness at higher doses. With aripiprazole, sedation may be additive.
How serious is the interaction between Aripiprazole and Diphenoxylate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep to labeled diphenoxylate doses and warn the patient about drowsiness and impaired alertness.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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