Drug interactions
Aripiprazole + Dosulepin
Severity: Moderate
Aripiprazole and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant that can add to aripiprazole sedation, orthostatic hypotension and anticholinergic effects. It may also prolong the QT interval and lower the seizure threshold.
What this interaction means in plain words
Aripiprazole and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Dosulepin belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects; aripiprazole may be affected by CYP2D6 inhibition in some cases.
What to do
Monitor sedation, blood pressure and ECG in at-risk patients, and start with low doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Aripiprazole with Dosulepin?
MediHelp rates the interaction as moderate. Aripiprazole and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant that can add to aripiprazole sedation, orthostatic hypotension and anticholinergic effects. It may also prolong the QT interval and lower the seizure threshold.
How serious is the interaction between Aripiprazole and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and ECG in at-risk patients, and start with low doses.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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