Drug interactions
Aripiprazole + Efavirenz
Severity: Moderate
Aripiprazole and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can lower aripiprazole concentrations through CYP3A4 induction, risking loss of psychiatric control. Both drugs have been linked to QT effects, although the aripiprazole effect is small.
What this interaction means in plain words
Aripiprazole and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Efavirenz belongs to Anti Virals.
Why it happens
CYP3A4 induction by efavirenz increases aripiprazole metabolism; possible additive QT effects.
What to do
Aripiprazole labeling advises doubling the dose over 1 to 2 weeks with strong CYP3A4 inducers. Monitor psychiatric response and reduce the dose when efavirenz is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Efavirenz?
MediHelp rates the interaction as moderate. Aripiprazole and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can lower aripiprazole concentrations through CYP3A4 induction, risking loss of psychiatric control. Both drugs have been linked to QT effects, although the aripiprazole effect is small.
How serious is the interaction between Aripiprazole and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Aripiprazole labeling advises doubling the dose over 1 to 2 weeks with strong CYP3A4 inducers. Monitor psychiatric response and reduce the dose when efavirenz is stopped.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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