Drug interactions
Aripiprazole + Entrectinib
Severity: Moderate
Aripiprazole and Entrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib prolongs QT and is also a weak CYP3A4 inhibitor. With aripiprazole, QT effects may be additive and aripiprazole exposure may rise slightly.
What this interaction means in plain words
Aripiprazole and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Entrectinib belongs to Oncology.
Why it happens
Additive QT prolongation, plus weak CYP3A4 inhibition.
What to do
Monitor ECG and electrolytes, and watch for aripiprazole adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Entrectinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Aripiprazole with Entrectinib?
MediHelp rates the interaction as moderate. Aripiprazole and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib prolongs QT and is also a weak CYP3A4 inhibitor. With aripiprazole, QT effects may be additive and aripiprazole exposure may rise slightly.
How serious is the interaction between Aripiprazole and Entrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for aripiprazole adverse effects.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
