Drug interactions
Aripiprazole + Fingolimod
Severity: Moderate
Aripiprazole and Fingolimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod can cause bradycardia and has been linked with QT effects, while aripiprazole has a low but possible QT liability. Combined use may modestly add to arrhythmia risk, particularly in patients with other risk factors.
What this interaction means in plain words
Aripiprazole and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Fingolimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and heart rate.
What to do
Obtain a baseline ECG and correct potassium and magnesium abnormalities. Use extra monitoring during fingolimod initiation in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Aripiprazole with Fingolimod?
MediHelp rates the interaction as moderate. Aripiprazole and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod can cause bradycardia and has been linked with QT effects, while aripiprazole has a low but possible QT liability. Combined use may modestly add to arrhythmia risk, particularly in patients with other risk factors.
How serious is the interaction between Aripiprazole and Fingolimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium abnormalities. Use extra monitoring during fingolimod initiation in patients with QT risk factors.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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