Drug interactions
Aripiprazole + Givinostat
Severity: Moderate
Aripiprazole and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and aripiprazole may contribute a small additional effect. The combination increases the potential for serious ventricular arrhythmia in at-risk patients.
What this interaction means in plain words
Aripiprazole and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain ECGs at initiation, during concomitant use, and when clinically indicated. Withhold givinostat if QTc exceeds 500 ms or rises more than 60 ms from baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Aripiprazole with Givinostat?
MediHelp rates the interaction as moderate. Aripiprazole and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval, and aripiprazole may contribute a small additional effect. The combination increases the potential for serious ventricular arrhythmia in at-risk patients.
How serious is the interaction between Aripiprazole and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at initiation, during concomitant use, and when clinically indicated. Withhold givinostat if QTc exceeds 500 ms or rises more than 60 ms from baseline.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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