Drug interactions
Aripiprazole + Glasdegib
Severity: Moderate
Aripiprazole and Glasdegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval, and aripiprazole may add a small additional effect. The combination raises the theoretical risk of torsades de pointes, especially with electrolyte disturbances or other risk factors.
What this interaction means in plain words
Aripiprazole and Glasdegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Glasdegib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and monitor it periodically, and correct potassium and magnesium. Consider an alternative to aripiprazole if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Aripiprazole with Glasdegib?
MediHelp rates the interaction as moderate. Aripiprazole and Glasdegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib can prolong the QT interval, and aripiprazole may add a small additional effect. The combination raises the theoretical risk of torsades de pointes, especially with electrolyte disturbances or other risk factors.
How serious is the interaction between Aripiprazole and Glasdegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and correct potassium and magnesium. Consider an alternative to aripiprazole if the QTc becomes markedly prolonged.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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