Drug interactions
Aripiprazole + Gliclazide
Severity: Moderate
Aripiprazole and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole can occasionally cause hyperglycemia or worsen glucose control, which may counteract gliclazide. The metabolic risk is lower than with some other atypical antipsychotics but is still present.
What this interaction means in plain words
Aripiprazole and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Gliclazide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as antipsychotic-related changes in insulin sensitivity and glucose metabolism oppose sulfonylurea action.
What to do
Monitor fasting glucose and HbA1c after starting aripiprazole. Adjust antidiabetic therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Gliclazide?
MediHelp rates the interaction as moderate. Aripiprazole and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole can occasionally cause hyperglycemia or worsen glucose control, which may counteract gliclazide. The metabolic risk is lower than with some other atypical antipsychotics but is still present.
How serious is the interaction between Aripiprazole and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting aripiprazole. Adjust antidiabetic therapy as required.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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