Drug interactions
Aripiprazole + Imipramine
Severity: Moderate
Aripiprazole and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and imipramine may also raise aripiprazole exposure because it can weakly inhibit CYP2D6. The result may be more drowsiness, orthostasis or other adverse effects.
What this interaction means in plain words
Aripiprazole and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus possible CYP2D6 inhibition by imipramine raising aripiprazole levels.
What to do
Monitor for sedation, orthostatic hypotension and akathisia. Adjust the aripiprazole dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Imipramine?
MediHelp rates the interaction as moderate. Aripiprazole and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and imipramine may also raise aripiprazole exposure because it can weakly inhibit CYP2D6. The result may be more drowsiness, orthostasis or other adverse effects.
How serious is the interaction between Aripiprazole and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and akathisia. Adjust the aripiprazole dose if adverse effects emerge.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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