Drug interactions
Aripiprazole + Insulin degludec-liraglutide
Severity: Moderate
Aripiprazole and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole can raise blood glucose in some patients, which may work against the glucose-lowering effect of the insulin degludec and liraglutide combination. Glycemic control may deteriorate, especially after starting or increasing the antipsychotic.
What this interaction means in plain words
Aripiprazole and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Atypical antipsychotics can impair glucose regulation, an effect that opposes the action of antidiabetic drugs; the effect is generally less marked with aripiprazole.
What to do
Check blood glucose more often when aripiprazole is started or the dose is changed, and adjust the insulin degludec-liraglutide dose if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Aripiprazole and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole can raise blood glucose in some patients, which may work against the glucose-lowering effect of the insulin degludec and liraglutide combination. Glycemic control may deteriorate, especially after starting or increasing the antipsychotic.
How serious is the interaction between Aripiprazole and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when aripiprazole is started or the dose is changed, and adjust the insulin degludec-liraglutide dose if hyperglycemia develops.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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